The Comparative Carcinogenicities of 2-acetylaminofluorene and Its N-hydroxy Metabolite in Mice, Hamsters, and Guinea Pigs.
نویسندگان
چکیده
* This investigation was supported by Grants CA-07175 and CRTY-5002 of the National Cancer Institute, United States Public Health Service ; by a grant from the Jane Coffin Childs Memorial Fund for Medical Research; and by the Alexander and Margaret Stewart Trust Fund. We wish to thank Mrs. Joan Craig, Mrs. Nancy Kehm, and Mrs. Diane McKechnie for valuable assistance. t Present address : Department of Pathology, University of Tokyo.
منابع مشابه
The N- and Ring-Hydroxylation of 2-Acetylaminofluorene during Carcinogenesis in the Rat* JAMES
The new major metabolite of @-acetylaminofluorene (AAF) in the rat, N-hydroxy AAF, was excreted in the urine as a conjugate in amounts that increased during car cinogenesis; the amount at 18 weeks was about 9 times that at 1@weeks. When 3methylcholanthrene, which greatly inhibits the carcinogenicity of AM?, was fed with AAF, the excretion of N-hydroxy-AAF remained low, while the excretion of 3a...
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The guinea pig is resistant to the hepatocarcinogenic effects of 2-acetylaminofluorene and 2-aminofluorene. This resist ance, however, is not due to the lack of a A/-hydroxylating enzyme in the liver which catalyzes the first and rate-limiting step to the activation of these chemicals to proximal carcino gens. It is shown that guinea pig liver microsomes can A/-hydroxylate both of these compoun...
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Monolayers of hepatocytes from mouse, hamster, rat, and guinea pig metabolized 2-acetylaminofluorene (AAF) to ether-extractable, water-soluble as well as covalently macromolecular bound products. Hamster hepatocytes showed the highest rate of formation of ether-extractable metabolites, rat and guinea pig the lowest. These species differences reflected mainly differences in the formation of 2-am...
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Previous reports that radioactivity was bound to liver RNA after administration of 2-acetylaminofluorene-9-14C or N-hydroxy-2-acetylaminofluorene-9-14C in species susceptible to the carcinogenic action of 2-acetylaminofluorene have been con firmed. Injection of l-hydroxy-2-acetylaminofluorene-l-14C, a noncarcinogenic metabolite of 2-acetylaminofluorene, did not result in any binding of radioact...
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ورودعنوان ژورنال:
- Cancer research
دوره 24 شماره
صفحات -
تاریخ انتشار 1964